Yes.

South Dakota baseball fans got a firsthand look at Babe Ruth during his 1922 barnstorming tour of the Midwest.
And fans in Sioux Falls had arguably the best show of all on Oct. 17, 1922. In a seven-paragraph story, the Argus Leader reported Ruth hit for the cycle (single, double, triple, home run), including a grand slam. About 1,500 fans attended the game. Rosters were filled by local players.
The Sioux Falls mayor declared a holiday and asked businesses to close early.
On Oct. 19, the tour visited Deadwood, where fans spent about $1.10 per ticket ($21 today) to see the New York Yankee pitch and go 2-for-4. The Rapid City Journal made note of a Deadwood pitcher who struck him out.
Ruth returned to South Dakota in 1948, flying out of Sioux Falls after stops in Iowa to promote youth baseball, two months before his death.
This fact brief responds to conversations such as this one.
Sources
605Sports.com, Oct. 19, 1922 - The day Babe Ruth played in Deadwood, South Dakota
Rapid City Journal, Deadwood's pitcher strikes out Ruth in exhibition game (1922 article)
The Daily Argus Leader, Babe Ruth pounds out homer with bases choked in exhibition (1922 article)
The Daily Argus Leader, Mayor declares Ruth holiday (1922 article)
Sioux Falls Argus Leader, The Canaries' oldest living player met Babe Ruth and got a hit off Don Larsen
Sioux Falls Argus Leader, photo of Babe Ruth at airport (1948 newspaper)
History.com, Babe Ruth dies
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